Urinary Tract Anti-Infectives:
- Sulfamethoxazole (Gantanol) – p.o.
- Sulfisoxazole (Gantrisin) – p.o.
- Nitrofurantoin (Macrodantin) – p.o.
- Co-Trimoxazole (Trimethoprim/Sulfamethoxazole) (Bactrim, Septra) – p.o., inj
- Methenamine (Mandelamine) – p.o.
UTI used to be the easiest thing to treat. Today, not so much. We have resistance not only in the hospital but in the community. Historically we used sulfonamides.
- Increasing resistance in hospital and community acquired infections
- Sulfonamides (“sulfa” drugs) alone are not very useful any more
Today a sulfa drug by itself can’t be used because resistance is very high. One way around it is by using a combination agent. We add trimethoprim with a sulfa drug to make a combination drug called Co-Trimoxazole (Bactrin). We also have the option of using Methenamine.